Endocrine Abstracts

Introduction: Hyperparathyroidism is a fairly common pathology that can cause functional and vital complications. Its treatment combines a medical component and a surgical one.The aim of this work is to specify the surgical indications for this pathology.Materials and methods: It is a retrospective study bringing 58 cases of secondary hyperparathyroidism collected over a period of 16 years (from 2001 to 2016).<p class="abstext"...

Introduction: Chronic lymphocytic thyroiditis is an autoimmune pathology affecting 5% of the population. Treatment is most often medical based on hormone treatment. Sometimes thyroiditis will be associated with benign or malignant nodular pathologies requiring the use of surgery. The objective of this study is to describe the diagnostic, therapeutic and evolutionary features of this entity.Materials and methods: It is a retrospective study bringing 28 ca...

Introduction: Thyroid carcinoma in childhood is rare, but may present with distant metastases. We present an unexpected diagnosis of follicular–variant papillary thyroid carcinoma (FVPTC) presenting to acute services with cyanosis.Case report: An 11-year old boy presented to A&E with a two month history of cyanosis, worse with exertion, but not associated with respiratory distress or limitation of exercise tolerance. He had peripheral cyanosis, ...

Introduction: Peutz-Jeghers syndrome (PJS) is a rare familial disorder with an incidence of one in 12–30,000 live births characterized by mucocutaneous pigmentation, gastrointestinal and extra gastrointestinal hamartomatous polyps and an increased risk of malignancy.Case presentation: We report a 22-year-old female hypothyroid since age of 4, type 1 diabetic since age of 11, who presented with melaena. Pigmentation of the buccal mucosa, multiple lip...

Objective: To evaluate semen parameters and measure serum FSH, LH, Testosterone (T) concentrations before and 6 weeks after i.v. (800–1200 mg elemental iron iron therapy in adults with iron deficiency anemia.Patients and methods: This study investigated 11 adults with iron deficiency anemia (IDA) aged 40±5 years, with full pubertal development (Tanner stage 5, eugonadal) and capacity to ejaculate. They had iron deficiency anemia mainly due to d...

Objectives: Diabetic ketoacidosis (DKA) remains a life-threatening emergency. An updated protocol was introduced in Sligo general hospital in 2009 to standardise DKA management. The aim of this study was to audit current practice against the protocol standards.Methods: Clinical notes of all adult patients admitted with DKA between July 2009 and June 2012 were analysed and retrospectively audited against the protocol.Results: Fifty-...

A 49 yrs old lady was referred to us as her primary hypothyroidism deteriorated after exacerbation of her ulcerative colitis (UC). She also has coeliac disease. Although on levothyroxine (oral T4) 175 mcg, her thyroid stimulating hormone (TSH) remained above 40 mU/L (0.35–5.00 mU/L), and free thyroxine (FT4) was <5.15 pmol/L (9.0–20.0 pmol/L). A step wise increase of oral T4 to 900 mcg proved no benefit. Changing oral T4 tablets to syrup and addition of low dose ...

Endometriotic tissues express oestrogen receptors and depend on oestrogen to proliferate, survive and cause symptoms, such as deep neuropathic pain, by recruiting neurones into the tissue. Raloxifene is an anti-oestrogen and so may prevent many of these effects and although the effect of raloxifene on endometriosis has not been directly assessed, low-dose use in a recent trial has been associated with a rapid return of pain symptoms. In this pilot study, pre-menopausal women w...

Nicotine (N) is known as the main toxic and addictive component of cigarette smoke. By its ability to generate reactive oxygen species (ROS) and oxidative damage in organism, it can induce major public health problems such as cancer, cardiovascular diseases and infertility. Green tea extract (GTE) is an important source of polyphenols catechins; it has attracted a great deal of attention around the world because of its potential antioxidants role in scavenging free radicals. T...

Background: Insulin, derived from a single chain precursor pro-insulin, is cleaved by convertases to form insulin (t1/2 – 4 min) and C-peptide (t1/2 – 30 min). The ratio of insulin to C-peptide levels, which is usually less than one, is reversed in presence of exogenous insulin and insulin autoimmune syndrome. We present the significance of insulin-C-peptide ratio (ICR) in the diagnostic algorithm for the investigation of endogenous hyperinsulinaemia.<p class="ab...